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Estimated delivery: Feb 12 ⁠– Feb 13

Guaranteed and fulfilled by Flagship

8-IN-1 BIOSERUM - 0.33 fl oz | 10ml | 2 week supply

Designed to deliver “treatment-like” results and is known as “microneedling in a bottle”.

The Multifaceted Anti-Aging Serum

Embrace the extraordinary capabilities of the 8-in-1 BioSerum, our multifunctional marvel in anti-aging skincare. Intuitively meeting your skin’s unique needs, this DefenAge's iconic bestseller is designed to deliver visible, targeted rejuvenation. As a biologically advanced serum concentrate, it features an unprecedented concentration of defensin molecules from the Age-Repair Defensin® Complex, affirming its position as a superior anti-aging serum. Esteemed by dermatologists as an excellent retinol alternative, the 8-in-1 BioSerum serves as a premier rejuvenation serum, either alone or in combination with retinol or bakuchiol serums. Experience the cumulative benefits of eight distinct serums and unveil your best skin ever with this rejuvenating serum.

The Standalone Skincare Wonder

Ideal as a solo skincare powerhouse, the 8-in-1 BioSerum is renowned as a "treatment multiplier" and likened to "microneedling in a bottle." Dermatologists recommend this rejuvenation serum for enhancing the results of aesthetic procedures such as microneedling, RF-microneedling, fractional and ablative laser treatments, and Sofwave. Explore how this anti-aging serum can amplify your treatment outcomes in the Clinical Studies tab.

Read expert opinions here.

Eight Serums in One: Embark on a Journey of Eightfold Rejuvenation

Dive deeper into the unique fusion offered by the 8-in-1 BioSerum. This innovative formula masterfully brings together the benefits of eight specialized serums, delivering a holistic approach to skincare that’s comprehensive and unparalleled:

  • 1. Anti-Oxidants Serum: A robust blend of antioxidants, including Ergothioneine, combats environmental damage while brightening and energizing the skin.
  • 2. Niacinamide Serum: Rich in high-performance Niacinamide (Vitamin B3), it soothes, hydrates, revitalizes the skin’s moisture barrier, and promotes a uniform skin tone.
  • 3. Hyaluronic Acid (HA) Serum: Infused with low-weight Hyaluronic Acid for deep hydration, supplemented by a suite of intense moisturizers.
  • 4. Collagen Serum: Enhanced with beta-defensin 3, the BioSerum boosts collagen, improves elasticity and firmness, and diminishes sagging.
  • 5. Calming Serum: Contains Sea Whip extract, the sea’s most potent and swift anti-inflammatory agent, effectively addressing inflamm’aging.
  • 6. Peptide Serum: A bespoke blend of peptides, including Palmitoyl Tripeptide-38, targets critical aging areas, smoothing wrinkles and refining skin texture.
  • 7. DNA-Repair Enzyme Serum: Features enzymes from Mediterranean Arabidopsis, renowned for repairing common DNA damage.
  • 8. Retinol-Alternative Serum: The crowning jewel of the 8-in-1 BioSerum is the highest concentration achievable of Alpha-Defensin 5—DefenAge’s exclusive and revolutionary ingredient. This bio-synthesized molecule marks a triumph in regenerative biology, renowned for its unparalleled ability to activate age-repair pathways, foster new skin development, and serve as a safe, highly effective alternative to retinol. The inclusion of Alpha-Defensin 5 represents not merely an advancement in skincare, but a paradigm shift in our approach to skin rejuvenation and anti-aging. The presence of this potent ingredient in the serum parallels the benefits of traditional retinol serums with a gentler approach, minimizing potential irritation and making it suitable for all skin types.

The 8-in-1 BioSerum transcends traditional skincare, unifying eight essential benefits for a youthful, radiant complexion. It's not just an anti-aging serum; it’s a complete solution for visible skin rejuvenation.

How Our BioSerum Works: The Essence of Anti-Aging and Rejuvenation

Experience the transformative effects of DefenAge's 8-in-1 BioSerum, an exceptional anti-aging and rejuvenation serum. This unique formula improves the overall health and appearance of your skin by:

  • •  Rejuvenating Smoothness: Enhancing visible skin health and quality.
  • •  Reducing Signs of Aging: Minimizing the look of fine lines, wrinkles, pores, and pigmentation.
  • •  Promoting Radiance: Reviving skin’s natural moisture for a luminous glow.
  • •  Brightening Skin Tone: Improving overall clarity and luminosity.
  • •  Renewing the Feeling of Firmness and Elasticity: Restoring texture for a youthful feel.
  • •  Calming Redness: Beneficial for sensitive skin, Helps improve the appearance of skin redness.
  • •  Promoting Skin Barrier and Immunity: Helps to Strengthen skin’s natural defenses for optimal health.
Why Choose Our 8-in-1 BioSerum: A Cut Above the Rest

Our rejuvenation serum stands out as a superior alternative to retinol and bakuchiol serums. The 8-in-1 BioSerum combines advanced, targeted treatment with validated science, creating an unparalleled skincare product:

  • •  Rich in Defensins: Contains five times more defensin molecules than other skincare formulas.
  • •  Feather-Light Feel: Offers a lightweight application for a comfortable wear.
  • •  Versatile Use: Safe and effective for the entire face, skin around eyes, lips, neck, and décolleté.
  • •  Targets Crepey Skin: Excelling on thin skin areas like the neck and arms.
  • •  Rapid Anti-Aging Effects: Delivers visible results within a few weeks.
  • •  Suitable for All: Ideal for daily use, for both men and women, and for all adult ages, including people above 70.
  • •  Gentle for Sensitive Skin: Non-irritating, retinol.
  • •  Broad Tolerance: Effective for diverse skin types, including those with rosacea and melasma.
  • •  Highly effective for pre- and post- aesthetic procedures: Enhances outcomes of aesthetic treatments like microneedling, fractional and ablative laser therapy. Primes the skin to a quick and robust response. Optimizes healing and minimizes the risk of acne break-outs post-procedure.
  • •  Pre-Filler Prime: Ideal for preparing skin before fillers — start using four to six weeks before procedures.
  • •  Customer Favorite: Known as DefenAge's most liked product with impressive feedback.

Made in the U.S.A.


  1. Shipping & returns

    Your shipping cost will be computed at checkout. You can return this item for free within 30 days of receiving the package. View our shipping and returns policy.

  2. About DefenAge Skincare

    Age on Your Own Terms | Unlock the power of Defensins: Regenerate and reveal your skin's youthful vitality through the fusion of innovative cellular science and nature's timeless wound-healing mechanisms.

    View Brand Page
Product image
Product image
8-in-1 BioSerum - 2 Week Supply

$56.00


Estimated delivery: Feb 12 ⁠– Feb 13

Guaranteed and fulfilled by Flagship

8-IN-1 BIOSERUM - 0.33 fl oz | 10ml | 2 week supply

Designed to deliver “treatment-like” results and is known as “microneedling in a bottle”.

The Multifaceted Anti-Aging Serum

Embrace the extraordinary capabilities of the 8-in-1 BioSerum, our multifunctional marvel in anti-aging skincare. Intuitively meeting your skin’s unique needs, this DefenAge's iconic bestseller is designed to deliver visible, targeted rejuvenation. As a biologically advanced serum concentrate, it features an unprecedented concentration of defensin molecules from the Age-Repair Defensin® Complex, affirming its position as a superior anti-aging serum. Esteemed by dermatologists as an excellent retinol alternative, the 8-in-1 BioSerum serves as a premier rejuvenation serum, either alone or in combination with retinol or bakuchiol serums. Experience the cumulative benefits of eight distinct serums and unveil your best skin ever with this rejuvenating serum.

The Standalone Skincare Wonder

Ideal as a solo skincare powerhouse, the 8-in-1 BioSerum is renowned as a "treatment multiplier" and likened to "microneedling in a bottle." Dermatologists recommend this rejuvenation serum for enhancing the results of aesthetic procedures such as microneedling, RF-microneedling, fractional and ablative laser treatments, and Sofwave. Explore how this anti-aging serum can amplify your treatment outcomes in the Clinical Studies tab.

Read expert opinions here.

Eight Serums in One: Embark on a Journey of Eightfold Rejuvenation

Dive deeper into the unique fusion offered by the 8-in-1 BioSerum. This innovative formula masterfully brings together the benefits of eight specialized serums, delivering a holistic approach to skincare that’s comprehensive and unparalleled:

  • 1. Anti-Oxidants Serum: A robust blend of antioxidants, including Ergothioneine, combats environmental damage while brightening and energizing the skin.
  • 2. Niacinamide Serum: Rich in high-performance Niacinamide (Vitamin B3), it soothes, hydrates, revitalizes the skin’s moisture barrier, and promotes a uniform skin tone.
  • 3. Hyaluronic Acid (HA) Serum: Infused with low-weight Hyaluronic Acid for deep hydration, supplemented by a suite of intense moisturizers.
  • 4. Collagen Serum: Enhanced with beta-defensin 3, the BioSerum boosts collagen, improves elasticity and firmness, and diminishes sagging.
  • 5. Calming Serum: Contains Sea Whip extract, the sea’s most potent and swift anti-inflammatory agent, effectively addressing inflamm’aging.
  • 6. Peptide Serum: A bespoke blend of peptides, including Palmitoyl Tripeptide-38, targets critical aging areas, smoothing wrinkles and refining skin texture.
  • 7. DNA-Repair Enzyme Serum: Features enzymes from Mediterranean Arabidopsis, renowned for repairing common DNA damage.
  • 8. Retinol-Alternative Serum: The crowning jewel of the 8-in-1 BioSerum is the highest concentration achievable of Alpha-Defensin 5—DefenAge’s exclusive and revolutionary ingredient. This bio-synthesized molecule marks a triumph in regenerative biology, renowned for its unparalleled ability to activate age-repair pathways, foster new skin development, and serve as a safe, highly effective alternative to retinol. The inclusion of Alpha-Defensin 5 represents not merely an advancement in skincare, but a paradigm shift in our approach to skin rejuvenation and anti-aging. The presence of this potent ingredient in the serum parallels the benefits of traditional retinol serums with a gentler approach, minimizing potential irritation and making it suitable for all skin types.

The 8-in-1 BioSerum transcends traditional skincare, unifying eight essential benefits for a youthful, radiant complexion. It's not just an anti-aging serum; it’s a complete solution for visible skin rejuvenation.

How Our BioSerum Works: The Essence of Anti-Aging and Rejuvenation

Experience the transformative effects of DefenAge's 8-in-1 BioSerum, an exceptional anti-aging and rejuvenation serum. This unique formula improves the overall health and appearance of your skin by:

  • •  Rejuvenating Smoothness: Enhancing visible skin health and quality.
  • •  Reducing Signs of Aging: Minimizing the look of fine lines, wrinkles, pores, and pigmentation.
  • •  Promoting Radiance: Reviving skin’s natural moisture for a luminous glow.
  • •  Brightening Skin Tone: Improving overall clarity and luminosity.
  • •  Renewing the Feeling of Firmness and Elasticity: Restoring texture for a youthful feel.
  • •  Calming Redness: Beneficial for sensitive skin, Helps improve the appearance of skin redness.
  • •  Promoting Skin Barrier and Immunity: Helps to Strengthen skin’s natural defenses for optimal health.
Why Choose Our 8-in-1 BioSerum: A Cut Above the Rest

Our rejuvenation serum stands out as a superior alternative to retinol and bakuchiol serums. The 8-in-1 BioSerum combines advanced, targeted treatment with validated science, creating an unparalleled skincare product:

  • •  Rich in Defensins: Contains five times more defensin molecules than other skincare formulas.
  • •  Feather-Light Feel: Offers a lightweight application for a comfortable wear.
  • •  Versatile Use: Safe and effective for the entire face, skin around eyes, lips, neck, and décolleté.
  • •  Targets Crepey Skin: Excelling on thin skin areas like the neck and arms.
  • •  Rapid Anti-Aging Effects: Delivers visible results within a few weeks.
  • •  Suitable for All: Ideal for daily use, for both men and women, and for all adult ages, including people above 70.
  • •  Gentle for Sensitive Skin: Non-irritating, retinol.
  • •  Broad Tolerance: Effective for diverse skin types, including those with rosacea and melasma.
  • •  Highly effective for pre- and post- aesthetic procedures: Enhances outcomes of aesthetic treatments like microneedling, fractional and ablative laser therapy. Primes the skin to a quick and robust response. Optimizes healing and minimizes the risk of acne break-outs post-procedure.
  • •  Pre-Filler Prime: Ideal for preparing skin before fillers — start using four to six weeks before procedures.
  • •  Customer Favorite: Known as DefenAge's most liked product with impressive feedback.

Made in the U.S.A.


  1. Shipping & returns

    Your shipping cost will be computed at checkout. You can return this item for free within 30 days of receiving the package. View our shipping and returns policy.

  2. About DefenAge Skincare

    Age on Your Own Terms | Unlock the power of Defensins: Regenerate and reveal your skin's youthful vitality through the fusion of innovative cellular science and nature's timeless wound-healing mechanisms.

    View Brand Page
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