Home
Categories
BrandsCollectionsBundlesSaleMy links
Product image
Product image

Estimated delivery: May 2 ⁠– May 3

Consistency is key, especially in your day and night skincare routine. By incorporating targeted products into your routine, you can nourish and protect your skin during the day and promote rejuvenation while you sleep.

Before the day, a DefenAge skincare routine in the morning offers essential protection and hydration. The 3D Eye Radiance Cream and 1-Step Multi-Cleanse help revitalize the delicate eye area and cleanse your skin, while the Barrier Balance Cream provides a shield against environmental stressors. Much like microneedling, Defensin-molecules help to activate dormant new skin cells within the body to address the appearance of fine lines. Our 8-in-1 BioSerum has the highest concentration of Age-Repair Defensins with a light-weight application making it perfect to incorporate as the last step of your daily regimen.

By consistently following a night skincare routine with DefenAge, you can awaken to visibly improved skin that looks and feels renewed. DefenAge's nighttime routine offers a range of powerful products designed to maximize your skin's rejuvenation potential. The 8-in-1 BioSerum, 24/7 Barrier Balance Cream, and 6-Week Perfection Neck Cream are key players in this routine, working synergistically to optimize cellular renewal, reduce the appearance of crepey skin, fine lines, and wrinkles, and restore moisture levels.

MORNING & NIGHT SKINCARE ROUTINE contains:
  • STEP 1: 1-Step Multi-Cleanse, 5.0 oz.
  • STEP 2 | FACE: 24/7 Barrier Balance Cream, 1.5 fl. oz.
  • STEP 2 | EYES: 3D Eye Radiance Cream, 0.5 fl. oz.
  • STEP 2 | NECK: 6 Week Perfection Neck Cream, 1.5 fl. oz.
  • STEP 3: 8-in-1 BioSerum, 1.5 fl. oz.

Having a daily skincare routine is important because it allows you to establish healthy habits and address specific skincare concerns, like crepey skin. Regularly cleansing, nourishing, and protecting your skin can help prevent damage, improve skin texture, and promote a more youthful appearance over time.

DefenAge's innovative products work together to promote cell renewal, diminish the signs of aging, and restore moisture. Perfect skincare for combination, dry , or oily skin. Embrace the power of nighttime skincare and give your skin the care it deserves, unlocking the secret to age-repair beauty.

All cosmetic products are made in the U.S.A.


  1. Shipping & returns

    Your shipping cost will be computed at checkout. Please visit the brand's website for more information on returns and exchanges. For more detailed information view our shipping and returns policy.

  2. About DefenAge Skincare

    Age on Your Own Terms | Unlock the power of Defensins: Regenerate and reveal your skin's youthful vitality through the fusion of innovative cellular science and nature's timeless wound-healing mechanisms.

    View Brand Page
About this product
  1. How to use


    STEP ONE | 1-Step Multi-Cleanse

    Daily: AM, PM

    Place dime-sized portion of cleansing gel onto fingertips. Gently massage over dry skin for 15 seconds. Moisten fingertips and massage using circular motions. Repeat until white cleansing milk develops. Rinse well with warm water. If desired, use a clean facecloth or cleansing sponge to remove excess cleanser. Pat dry with clean towel. Follow with STEP TWO (24/7 Barrier Balance Cream, 3D Eye Radiance Cream, and 6-Week Perfection Neck Cream).

    Suitable for all skin types.

     

     


    STEP TWO - FACE | 24/7 Barrier Balance Cream

    Daily: AM, PM

    Twice daily after cleansing, place up to 2 pumps of cream onto fingertips. While skin is still moist, lightly massage with fingertips over entire face. Avoid eye area. Wait 30 seconds; then apply STEP THREE (8-in-1 BioSerum).

    Suitable for all skin types.

     

     


    STEP TWO - EYES | 3D Eye Radiance Cream

    Daily: AM, PM

    After cleansing, while the skin is still moist from rinsing, pump a drop of radiant under-eye treatment onto the applicator. Lightly dab three dots of dark circle eye cream below each eye. If not applying eye makeup, continue to apply to the upper eyelid, but avoid contact with eyes and eye lashes. Using the applicator, massage cream around the eyes.

    Suitable for all skin types.

     

     


    STEP TWO - NECK | 6-Week Perfection Neck Cream

    Daily: PM

    Twice daily after cleansing, place 1 pump of the neck tightening cream onto fingertips. While skin is still moist, lightly massage cream onto the skin with short lifting motions using fingers of right hand to apply to left side of neck and décolleté, and vice versa. Start above breast line and work up to jawline and back of neck. Wait 30 seconds, then apply STEP THREE (8-in-1 BioSerum).

    Suitable for all skin types.

     

     


    STEP THREE | 8-in-1 BioSerum

    Daily: AM, PM

    Apply after the 24/7 Barrier Balance Cream,

    and 6-Week Perfection Neck Cream.

    30 seconds after applying STEP TWO, place 1 pump of serum onto fingertips. While skin is still moist, lightly massage with fingertips first around eyes, then over entire face. Use a second pump on neck and décolleté. 

    Suitable for all skin types.

  2. Clinical studies


    DefenAge is proven in more than 30 clinical studies. All DefenAge formulas are dermatologist tested. 1-Step Multi-Cleanse, 3D Eye Radinace Cream, and 8-in-1 BioSerum are also ophthalmologist tested.


    Multi-center placebo-controlled double-blind clinical study shows that DefenAge “globally improves the visual appearance of aging skin” and “offers most of the advantages of time-honored retinols as well as newer but widely used growth-factor containing cosmeceuticals, without irritation or inflammation, sun-sensitivity, or concerns about neoplasia of the treated skin.”

    Journal of Drugs in Dermatology 2018, 17(4): p. 426-441Amy Taub MD, Vivian Bucay MD, Gregory Keller MD, Jay Williams PhD, and Darius Mehregan MD

  3. Ingredients


    KEY PERFORMANCE INGREDIENTS & TECHNOLOGIES

     

    Age-Repair Defensins® | DefenAge's Exclusive

    promotes new skin • anti-aging on a global scale

    Defensins are natural molecules. They signal our body to create new skin by activating the dormant reserves of "fresh" and young cells. DefenAge contains an identical copy of human defensins made via bio-synthesis; defensins are exclusive to DefenAge.


    Niacinamide

    hydration • firmness & elasticity • brightening

    Soothes, revives the skin’s natural moisture barrier, renews the feel of skin firmness and elasticity, and brightens overall skin tone.


    Hyaluronic Acid

    Liposome Encapsulated (Face Cream) | Low Molecular Weight (Serum)

    • hydration •

    Promotes hydration and improves texture for remarkably smooth and even skin.


    Sea Whip

    • skin calming & soothing •

    Keeps skin calm. Strongest, fastest, most effective soothing ingredient from the sea.


    Ophiopogon Japonicus Root Extract and

    Sinorhizobium Meliloti Ferment

    skin's barrier balance • natural hydration

    The powerful blend of natural extracts balances the skin’s barrier, saves the skin’s natural moisture, and promotes the levels of Natural Moisturization Factors (NMFs).

     

    Squalene

    moisturiozation • antioxidant 

    Energizes skin hydration. Prevents moisture loss while restoring visible skin’s suppleness and flexibility. Fights skin damage and free radicals.

     

     

    Panthenol

    soothing • protection

    Helps the skin build up a barrier against irritation and improves visible elasticity and smooth appearance. Hydrates the skin from within. Proven humectant.

     

     

    Fine Blends of Natural Antioxidants, Enzymes

    and Hydrating Technologies

    antioxidants • hydration • soothing

    Our “know-how”-protected, advanced and powerful blends of antioxidants and enzymes address environmental cell damage and defend against free radicals. They brighten, clarify and energize the skin for a revitalized radiance and luminosity.


    CLEAN BEAUTY

    This set contains seven of DefenAge’s top products; all of them are formulated based on the enhanced clean beauty standards. Find more information about our standards and why we raised the bar for skincare safety requirements on our Clean Beauty page.


    GREEN PLANET

    The bottles, tubes, and boxes are fully recyclable, please recycle.

    Not tested on animals.


    INGREDIENT LISTS

    The detailed ingredient lists can be reviewed on the individual product pages:

     

    1-Step Multi-Cleanse ►

    24/7 Barrier Balance Cream ►

    3D Eye Radinace Cream ►

    6-Week Perfection Neck Cream ►

    8-in-1 BioSerum ►

     


    WARNINGS

    For external use only. Keep out of eyes. If product enters eyes rinse thoroughly with water. Discontinue use and consult a physician if irritation or allergy develops. Keep out of the reach of children.


Product image
Product image
MORNING AND NIGHT ROUTINE

$396.85


Consistency is key, especially in your day and night skincare routine. By incorporating targeted products into your routine, you can nourish and protect your skin during the day and promote rejuvenation while you sleep.

Before the day, a DefenAge skincare routine in the morning offers essential protection and hydration. The 3D Eye Radiance Cream and 1-Step Multi-Cleanse help revitalize the delicate eye area and cleanse your skin, while the Barrier Balance Cream provides a shield against environmental stressors. Much like microneedling, Defensin-molecules help to activate dormant new skin cells within the body to address the appearance of fine lines. Our 8-in-1 BioSerum has the highest concentration of Age-Repair Defensins with a light-weight application making it perfect to incorporate as the last step of your daily regimen.

By consistently following a night skincare routine with DefenAge, you can awaken to visibly improved skin that looks and feels renewed. DefenAge's nighttime routine offers a range of powerful products designed to maximize your skin's rejuvenation potential. The 8-in-1 BioSerum, 24/7 Barrier Balance Cream, and 6-Week Perfection Neck Cream are key players in this routine, working synergistically to optimize cellular renewal, reduce the appearance of crepey skin, fine lines, and wrinkles, and restore moisture levels.

MORNING & NIGHT SKINCARE ROUTINE contains:
  • STEP 1: 1-Step Multi-Cleanse, 5.0 oz.
  • STEP 2 | FACE: 24/7 Barrier Balance Cream, 1.5 fl. oz.
  • STEP 2 | EYES: 3D Eye Radiance Cream, 0.5 fl. oz.
  • STEP 2 | NECK: 6 Week Perfection Neck Cream, 1.5 fl. oz.
  • STEP 3: 8-in-1 BioSerum, 1.5 fl. oz.

Having a daily skincare routine is important because it allows you to establish healthy habits and address specific skincare concerns, like crepey skin. Regularly cleansing, nourishing, and protecting your skin can help prevent damage, improve skin texture, and promote a more youthful appearance over time.

DefenAge's innovative products work together to promote cell renewal, diminish the signs of aging, and restore moisture. Perfect skincare for combination, dry , or oily skin. Embrace the power of nighttime skincare and give your skin the care it deserves, unlocking the secret to age-repair beauty.

All cosmetic products are made in the U.S.A.


  1. Shipping & returns

    Your shipping cost will be computed at checkout. Please visit the brand's website for more information on returns and exchanges. For more detailed information view our shipping and returns policy.

  2. About DefenAge Skincare

    Age on Your Own Terms | Unlock the power of Defensins: Regenerate and reveal your skin's youthful vitality through the fusion of innovative cellular science and nature's timeless wound-healing mechanisms.

    View Brand Page
About this product
  1. How to use


    STEP ONE | 1-Step Multi-Cleanse

    Daily: AM, PM

    Place dime-sized portion of cleansing gel onto fingertips. Gently massage over dry skin for 15 seconds. Moisten fingertips and massage using circular motions. Repeat until white cleansing milk develops. Rinse well with warm water. If desired, use a clean facecloth or cleansing sponge to remove excess cleanser. Pat dry with clean towel. Follow with STEP TWO (24/7 Barrier Balance Cream, 3D Eye Radiance Cream, and 6-Week Perfection Neck Cream).

    Suitable for all skin types.

     

     


    STEP TWO - FACE | 24/7 Barrier Balance Cream

    Daily: AM, PM

    Twice daily after cleansing, place up to 2 pumps of cream onto fingertips. While skin is still moist, lightly massage with fingertips over entire face. Avoid eye area. Wait 30 seconds; then apply STEP THREE (8-in-1 BioSerum).

    Suitable for all skin types.

     

     


    STEP TWO - EYES | 3D Eye Radiance Cream

    Daily: AM, PM

    After cleansing, while the skin is still moist from rinsing, pump a drop of radiant under-eye treatment onto the applicator. Lightly dab three dots of dark circle eye cream below each eye. If not applying eye makeup, continue to apply to the upper eyelid, but avoid contact with eyes and eye lashes. Using the applicator, massage cream around the eyes.

    Suitable for all skin types.

     

     


    STEP TWO - NECK | 6-Week Perfection Neck Cream

    Daily: PM

    Twice daily after cleansing, place 1 pump of the neck tightening cream onto fingertips. While skin is still moist, lightly massage cream onto the skin with short lifting motions using fingers of right hand to apply to left side of neck and décolleté, and vice versa. Start above breast line and work up to jawline and back of neck. Wait 30 seconds, then apply STEP THREE (8-in-1 BioSerum).

    Suitable for all skin types.

     

     


    STEP THREE | 8-in-1 BioSerum

    Daily: AM, PM

    Apply after the 24/7 Barrier Balance Cream,

    and 6-Week Perfection Neck Cream.

    30 seconds after applying STEP TWO, place 1 pump of serum onto fingertips. While skin is still moist, lightly massage with fingertips first around eyes, then over entire face. Use a second pump on neck and décolleté. 

    Suitable for all skin types.

  2. Clinical studies


    DefenAge is proven in more than 30 clinical studies. All DefenAge formulas are dermatologist tested. 1-Step Multi-Cleanse, 3D Eye Radinace Cream, and 8-in-1 BioSerum are also ophthalmologist tested.


    Multi-center placebo-controlled double-blind clinical study shows that DefenAge “globally improves the visual appearance of aging skin” and “offers most of the advantages of time-honored retinols as well as newer but widely used growth-factor containing cosmeceuticals, without irritation or inflammation, sun-sensitivity, or concerns about neoplasia of the treated skin.”

    Journal of Drugs in Dermatology 2018, 17(4): p. 426-441Amy Taub MD, Vivian Bucay MD, Gregory Keller MD, Jay Williams PhD, and Darius Mehregan MD

  3. Ingredients


    KEY PERFORMANCE INGREDIENTS & TECHNOLOGIES

     

    Age-Repair Defensins® | DefenAge's Exclusive

    promotes new skin • anti-aging on a global scale

    Defensins are natural molecules. They signal our body to create new skin by activating the dormant reserves of "fresh" and young cells. DefenAge contains an identical copy of human defensins made via bio-synthesis; defensins are exclusive to DefenAge.


    Niacinamide

    hydration • firmness & elasticity • brightening

    Soothes, revives the skin’s natural moisture barrier, renews the feel of skin firmness and elasticity, and brightens overall skin tone.


    Hyaluronic Acid

    Liposome Encapsulated (Face Cream) | Low Molecular Weight (Serum)

    • hydration •

    Promotes hydration and improves texture for remarkably smooth and even skin.


    Sea Whip

    • skin calming & soothing •

    Keeps skin calm. Strongest, fastest, most effective soothing ingredient from the sea.


    Ophiopogon Japonicus Root Extract and

    Sinorhizobium Meliloti Ferment

    skin's barrier balance • natural hydration

    The powerful blend of natural extracts balances the skin’s barrier, saves the skin’s natural moisture, and promotes the levels of Natural Moisturization Factors (NMFs).

     

    Squalene

    moisturiozation • antioxidant 

    Energizes skin hydration. Prevents moisture loss while restoring visible skin’s suppleness and flexibility. Fights skin damage and free radicals.

     

     

    Panthenol

    soothing • protection

    Helps the skin build up a barrier against irritation and improves visible elasticity and smooth appearance. Hydrates the skin from within. Proven humectant.

     

     

    Fine Blends of Natural Antioxidants, Enzymes

    and Hydrating Technologies

    antioxidants • hydration • soothing

    Our “know-how”-protected, advanced and powerful blends of antioxidants and enzymes address environmental cell damage and defend against free radicals. They brighten, clarify and energize the skin for a revitalized radiance and luminosity.


    CLEAN BEAUTY

    This set contains seven of DefenAge’s top products; all of them are formulated based on the enhanced clean beauty standards. Find more information about our standards and why we raised the bar for skincare safety requirements on our Clean Beauty page.


    GREEN PLANET

    The bottles, tubes, and boxes are fully recyclable, please recycle.

    Not tested on animals.


    INGREDIENT LISTS

    The detailed ingredient lists can be reviewed on the individual product pages:

     

    1-Step Multi-Cleanse ►

    24/7 Barrier Balance Cream ►

    3D Eye Radinace Cream ►

    6-Week Perfection Neck Cream ►

    8-in-1 BioSerum ►

     


    WARNINGS

    For external use only. Keep out of eyes. If product enters eyes rinse thoroughly with water. Discontinue use and consult a physician if irritation or allergy develops. Keep out of the reach of children.


Flagship helps creators work with 500+ brands

Create a shop on Flagship in less than 5 minutes, and we will help you with the heavy lifting.



© 2025 Flagship. All rights reserved.

Flagship helps creators work with 500+ brands

Create a shop on Flagship in less than 5 minutes, and we will help you with the heavy lifting.

Customer support

Support Goals to Get Glowing

Flagship helps creators like Goals to Get Glowing build business with a storefront and access to brands and deals to share with their community.

© 2025 Flagship. All rights reserved.